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Classes of Autoimmune Diseases

      Autoimmune Diseases can be broadly divided into systemic and organ-specific or localized autoimmune disorders, depending on the principal clinico - pathologic features of each disease. An example of systemic autoimmune diseases include; SLE, Sjögren's Syndrome, Sarcoidosis, Scleroderma, Rheumatoid Arthritis, and Dermatomyositis. These conditions tend to be associated with auto-antibodies to antigens which are not tissue specific. Using the traditional “organ specific” and “non-organ specific” classification scheme, many diseases have been lumped together under the autoimmune disease umbrella.
classes of autoimmune diseases
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     A condition is said to be "autoimmune"  when antibodies and immune cells are launched by the body against one or several antigens of its own tissues. Since most of the target antigens have now been discovered, the corresponding auto-antibodies can often be measured in the blood as markers for the corresponding autoimmune diseases. Please Note; this is not a detailed all inclusive listing of autoimmune diseases. Listed below are 80 known diseases, with exception to Ménière Disease,  Multiple Sclerosis,  and  Temporal Arteritis.

Systemic Diseases & Organ / Non Organ Specific Disorders Systemic Disorders involve auto antibodies that are not specific to antigens found on certain tissues. Examples include: Diseases Are Listed From A - Z

Systemic Diseases & Specifications

  • Ankylosing Spondylitis (AS) - systemic / multiple organs

  • Arthritis - systemic  / multiple joints, bones

  • Asthma - respiratory; lungs

  • Atopic Allergy - multiple organs

  • Autoimmune Inner Ear Disease - inner ear, brain; headache...

  • Balo Disease - variant of multiple sclerosis

  • Behcet's Disease - systemic / specific organs

  • Berger's Disease - systemic / progressive traits

  • Cardiomyopathy - organ specific; heart muscles

  • Chronic Fatigue Syndrome - systemic / multiple organs

  • Chung-Strauss Syndrome - systemic  / multiple organs

  • Cold Agglutinin Disease - systemic  / specific areas

  • Cranial Arteritis - systemic / rheumatic specific arteries

  • CREST Syndrome - systemic / multiple organs

  • Dego's Disease - systemic / develops; other organs

  • Dermatomyositis - systemic / multiple organs

  • Fibromyalgia - systemic / develop; other organs

  • Fibrosing Alveolitis - systemic / organ specific; lungs

  • Goodpastures Syndrome - organ specific; lungs, kidneys...

  • Graves Disease - systemic / multiple organs

  • Idiopathic Pulmonary Fibrosing - systemic / organs specific; lungs
  • Lupus - systemic / multiple organs

  • Lyme Disease - systemic / multiple areas
 
  • MCTD (mixed connective tissue disease) - systemic / multiple diseases
 
  • Myositis - systemic / muscles
 
  • Osteoporosis - systemic / bones
 
  • Par Planitis - organ specific; eyes
 
  • Pemphigus Vulgaris - organ specific; inside of mouth
 
  • Polymyalgia Rheumatica - systemic / muscles
 
  • Polymyositis - systemic / muscles
 
  • Raynaud's Syndrome - organ specific; fingers, toes, varies...
 
  • Reactive Arthritis - systemic / multiple organs
 
  • Rheumatic Fever - systemic / multiple organs
 
  • Rheumatoid Arthritis - systemic / various organs
 
  • Scleritis - associate diseases; RA, Lupus, AS...
 
  • Scleroderma - systemic / varies versions exist...
 
  • Sjögren's Syndrome - systemic / multiple organs
 
  • Still’s Disease - systemic / multiple organs
 
  • Vasculitis - systemic / blood vessel
 
  • Wegener's Granulomatosis - systemic / multiple organs etc...
 
  • Wilson's Syndrome - multiple organs affected

     Using the traditional “organ specific” and “non-organ specific” classification scheme, many diseases have been lumped together under the autoimmune disease umbrella.

Hashimoto's Thyroiditis - an autoimmune disease in which the thyroid gland is attacked by a variety of cell- and antibody-mediated immune processes. It was the first disease to be recognized as an autoimmune disease.

Lupus SLE - Non-infectious chronic disease in which antibodies in an individual's immune system attack the body's own substances. In lupus, known medically as lupus erythematosus, antibodies are produced against the individual's own cells, causing tissue inflammation and cell damage.

Rheumatoid Arthritis - Chronic, progressive autoimmune disease causing connective-tissue inflammation, mostly in synovial joints. It can occur at any age, is more common in women, and has an unpredictable course. It usually starts gradually, with pain and stiffness in one or more joints, then swelling and heat.

summary of autoimmune diseases

Multiple Sclerosis (MS) - a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.

Asthma - a common long term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm.

Celiac Disease - a long term autoimmune disorder primarily affecting the small intestine that occurs in people who are genetically predisposed.


Dermatitis -  also known as Eczema, is a group of diseases that results in inflammation of the skin. Psoriasis - a long-lasting autoimmune disease which is characterized by patches of abnormal skin.


Localized Autoimmune Diseases & Disorders Examples of localized disorders that are specific to a particular tissue, organ, or system can be divided into the following groups: Diseases are listed from A - Z under it's specific localization.

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Integumentary System (SKIN)
Endocrine System
Nervous System
Circulatory System
Digestive System

Dermatologic

  • Alopecia Areata

  • Atopic Dermatitis
 
  • Bullous Pemphigoid
 
  • Cicatricial Pemphigoid
 
  • Eczema
 
  • Eosinophilic Fasciitis
 
  • Lichen Planus
 
  • Psoriasis

Endocrinologic

  • Addison's Disease

  • Anti GBM-Nephritis 
 
  • Autoimmune  Hepatitis
 
  • Glomerular
  • Nephritis
 
  • Hashimoto's Thyroiditis
 
  • Hepatitis
 
  • Lupoid Hepatitis
 
  • Polyglandular Autoimmune Syndromes
 
  • Primary Sclerosing  Cholangitis

Neurologic

  • Acute Disseminated Encephalomyelitis

  • Amyotrophic Lateral Sclerosis (ALS)

  • Devic's Disease

  • Guillain–Barré Syndrome

  • Stiff Man Syndrome

  • Sydenham's Chorea

Hematologic

  • Agammaglobulinemia

  • Antiphospholipid Syndrome
 
  • Autoimmune Hemolytic Anemia
 
  • Cryoglobulinemia
 
  • Idiopathic Thrombocytopenic Purpura
 
  • Kawasaki Disease
 
  • Takayasu's Arteritis
 
  • Vasculitis

Gastrointestinal

  • Colitis                 

  • Crohn's Disease          
 
  • Inflammatory Bowel Diseases
 
  • Irritable Bowel Syndrome
 
  • Primary Biliary Cirrhosis
 
  • Ulcerative Colitis
summary of autoimmune diseases
  • Autoimmune Diseases result from a breakdown in immunological tolerance. The actual induction event(s) for autoimmune states are largely unknown.

  • Some autoimmune diseases attack specific organs, whereas others are more systemic.

  • Organ-specific autoimmune diseases include Celiac Disease, Graves disease, Hashimoto Thyroiditis, Type I Diabetes Mellitus, and Addison Disease.

  • Systemic autoimmune diseases include Multiple Sclerosis, Myasthenia Gravis, Psoriasis, Rheumatoid Arthritis, and Systemic Lupus Erythematosus.

  • Treatments for autoimmune diseases generally involve anti-inflammatory and immuno-suppressive drugs.

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Endocrine System

Muscular System

Skeletal System

Nervous System

Signs & Symptoms

Affected Body Parts

PDF Publication No. 763voeh4djfjg545  Printed & Published In U.S.A. Weishendo Publications authorizes reprinting of this publication. ©2017 Weishendo Publications
Page was last checked and verified on June 12, 2018

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